1. explain the normal  microbiota of humans and their benefits

2. list emerging factors and predisposing factors

3. describe virulence factors involved in adherence and colonization, invasion and spreading: surface structures, enzymes, endotoxins, exotoxins

4. explain phagocytosis, , fever and pyrogens, antimicrobial substances of body, interferon, complement system, NK cells, cell-mediated and humoral immunity

5. describe stages of inflammation, mediators and molecular mechanisms

6. understand disease development and relevant phases, nosocomial infections, epidemiology and modes of transmission

7. describe “Human Microbiome Project”, relevant research methods, future prospects including microbiome and  autoimmune diseases, obesity and neuro-chemical imbalances

8. distinguish between Gram-positive (Type I, II, III, V, Tat and SRP) secretion systems and their significance in pathogenesis

9. explain the roles of biofilm formation, quorum sensing and antigenic variation in pathogenesis

10. classify microbial pathogens with respect to their nature (intracellular bacterial pathogens and viruses) with selected examples to respiratory, gastrointestinal, urogenital systems

11. understand systems biology approaches applied to  pathogens and hosts, as well as their utility in drug and vaccine design